Corpus ID: 118547113

Predictions regarding the supply of 99Mo and 99mTc when NRU ceases production in 2018

  title={Predictions regarding the supply of 99Mo and 99mTc when NRU ceases production in 2018},
  author={C. K. Ross and William T. Diamond},
  journal={arXiv: Medical Physics},
The NRU reactor in Chalk River had been scheduled to stop producing medical isotopes by the end of 2016 but the Government of Canada recently announced that it will remain available to support isotope production until its operating license expires on 31 March, 2018. NRU has the capability of producing up to 80 % of the world's requirements for 99Mo but is presently producing less than 20 %. There are a number of initiatives underway, both within Canada and around the world, to find alternative… Expand

Figures from this paper

Production of 99Mo/99mTc via photoneutron reaction using natural molybdenum and enriched 100Mo: part 1, theoretical analysis
A theoretical analysis was performed for the production of 99Mo via the 100Mo(γ,n)99Mo reaction using natural (natMo) and enriched (100Mo) molybdenum targets in a modified NIRTA® Targetry system.Expand
Feasibility Study on Mo-99 Production Using Hybrid Method Based on High Power Electron Accelerator
In this study, the idea 99Mo production using hybrid method based on electron accelerator has been presented. Two different main production channels, 100Mo(γ,n)99Mo and 98Mo(n,γ)99Mo, can be used forExpand
The Radiopharmaceutical Chemistry of Technetium-99m
Technetium-99m (99mTc) is a radiometal that has nearly ideal nuclear properties for diagnostic nuclear medicine imaging, which has helped make it high impact and extensively utilized radionuclide inExpand
A Picture of Modern Tc-99m Radiopharmaceuticals: Production, Chemistry, and Applications in Molecular Imaging
Even today, techentium-99m represents the radionuclide of choice for diagnostic radio-imaging applications. Its peculiar physical and chemical properties make it particularly suitable for medicalExpand


Implementation of Multi-Curie Production of 99mTc by Conventional Medical Cyclotrons
The direct production of 99mTc via proton bombardment of 100Mo can be practically achieved in high yields using conventional medical cyclotrons, which eliminates the need for enriched uranium and the radioactive waste associated with the processing of uranium targets. Expand
Theoretical modeling of yields for proton-induced reactions on natural and enriched molybdenum targets.
The proposed approach allows us to theoretically estimate the amount of (99m)Tc and its ratio relative to (99g)TC and other radioisotopes which must be considered reaction contaminants, potentially contributing to additional patient dose in diagnostic studies. Expand
99Mo/(99m)Tc separation: an assessment of technology options.
Based on the analysis provided in this review, it appears that some proven separation technologies can be quickly resurrected for the separation of clinical grade (99m)Tc from macroscopic levels of reactor or cyclotron irradiated molybdenum targets. Expand
A System of 99mTc Production Based on Distributed Electron Accelerators and Thermal Separation
A system has been developed for the production of {sup 99m}Tc based on distributed electron accelerators and thermal separation. The radioactive decay parent of {sup 99m}Tc, {sup 99}Mo, is producedExpand
The Medical Isotope Crisis: How We Got Here and Where We Are Going
  • T. Ruth
  • Environmental Science, Medicine
  • The Journal of Nuclear Medicine Technology
  • 2014
How the 99Mo/99mTc pair was reached and what the near and distant future holds for securing the availability of these radioisotopes are examined. Expand
New technetium-99m generator technologies utilizing polyethylene glycol-based aqueous biphasic systems
Abstract Two new schemes for TcO4 −/MoO4 2− separations from OH− and MoO4 2− media using polyethylene glycol (PEG)-based aqueous biphasic systems (ABS) have been developed. The two most importantExpand
A comparison of rat SPECT images obtained using (99m)Tc derived from 99Mo produced by an electron accelerator with that from a reactor.
This study demonstrated the delivery of (99m)Tc from the end of beam to the end user of approximately 30 h, and images obtained using the heart and bone scanning agents using reactor and linac-produced (99)Mo were comparable. Expand
Magnetically activated and guided isotope separation
We propose a general method for efficient isotope separation. The principle of operation is based on an irreversible change of the mass-to-magnetic moment ratio of a particular isotope in an effusiveExpand
How We Got Here and Where We Are Going
Human Natures Genes, Cultures, and the Human Prospect. Paul R. Ehrlich. Island Press, Washington, DC, 2000. 543 pp. $29.95. ISBN 1-55963-779-X. Ehrlich presents a narrative of human evolutionaryExpand
A new approach for manufacturing and processing targets used to produce Tc with cyclotrons,
  • Proceedings of the 15 International Workshop on Targetry and Target Chemistry,
  • 2014