Prediction stability in a data-based, mechanistic model of σF regulation during sporulation in Bacillus subtilis

@article{Fengos2013PredictionSI,
  title={Prediction stability in a data-based, mechanistic model of $\sigma$F regulation during sporulation in Bacillus subtilis},
  author={Georgios Fengos and Dagmar Iber},
  journal={Scientific Reports},
  year={2013},
  volume={3}
}
Mathematical modeling of biological networks can help to integrate a large body of information into a consistent framework, which can then be used to arrive at novel mechanistic insight and predictions. We have previously developed a detailed, mechanistic model for the regulation of σ F during sporulation in Bacillus subtilis. The model was based on a wide range of quantitative data, and once fitted to the data, the model made predictions that could be confirmed in experiments. However, the… 
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