Prediction of working memory performance in schizophrenia by plasma ratio of clozapine to N-desmethylclozapine.

Abstract

OBJECTIVE Clozapine's potent antagonism of muscarinic M1 receptors is thought to worsen working memory deficits associated with schizophrenia. In contrast, its major metabolite, N-desmethylclozapine (NDMC), is thought to enhance working memory via its M1 receptor agonist activity. The authors hypothesized that the ratio of serum clozapine and NDMC… (More)
DOI: 10.1176/appi.ajp.2015.14050673

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Cite this paper

@article{Rajji2015PredictionOW, title={Prediction of working memory performance in schizophrenia by plasma ratio of clozapine to N-desmethylclozapine.}, author={Tarek K Rajji and Benoit H. Mulsant and Simon Davies and Sawsan M Kalache and Christopher Tsoutsoulas and Bruce G. Pollock and Gary Remington}, journal={The American journal of psychiatry}, year={2015}, volume={172 6}, pages={579-85} }