Prediction of working memory performance in schizophrenia by plasma ratio of clozapine to N-desmethylclozapine.

  title={Prediction of working memory performance in schizophrenia by plasma ratio of clozapine to N-desmethylclozapine.},
  author={Tarek K Rajji and Benoit H. Mulsant and Simon Davies and Sawsan M Kalache and Christopher Tsoutsoulas and Bruce G. Pollock and Gary J. Remington},
  journal={The American journal of psychiatry},
  volume={172 6},
OBJECTIVE Clozapine's potent antagonism of muscarinic M1 receptors is thought to worsen working memory deficits associated with schizophrenia. In contrast, its major metabolite, N-desmethylclozapine (NDMC), is thought to enhance working memory via its M1 receptor agonist activity. The authors hypothesized that the ratio of serum clozapine and NDMC concentrations would be inversely associated with working memory performance in schizophrenia. METHOD Thirty patients with schizophrenia or… CONTINUE READING


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