Prediction of tricyclic antidepressant response: a critical review.

  title={Prediction of tricyclic antidepressant response: a critical review.},
  author={Robert J Bielski and Robert O. Friedel},
  journal={Archives of general psychiatry},
  volume={33 12},
This article reviews all the prospective, double-blind controlled studies that have evaluated the prediction of response to imipramine hydrochloride and amitriptyline hydrochloride in depressed patients. Despite widely divergent methodologies, an attempt is made to extract clinically useful conclusions from these data. Critiques of each study and the criteria used in their evaluation are presented, with suggestions for future research included. The predictors of positive response to imipramine… CONTINUE READING


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