Prediction of time to progression after orchiectomy by the nuclear androgen receptor content from multiple biopsy specimens in patients with advanced prostate cancer.

@article{Aubel1988PredictionOT,
  title={Prediction of time to progression after orchiectomy by the nuclear androgen receptor content from multiple biopsy specimens in patients with advanced prostate cancer.},
  author={O G van Aubel and Joan B. Bolt-de Vries and Marinus A. Blankenstein and Fritz H. Schroeder},
  journal={The Prostate},
  year={1988},
  volume={12 3},
  pages={191-8}
}
The nuclear androgen receptor (ARn) content of cancerous prostatic tissue has been investigated as a prognosticator for time to progression under endocrine therapy. In 1981 a prospective study was started to investigate whether the ARn content in biopsy specimens of patients with prostatic carcinoma predicts the duration of response following hormonal treatment. ARn was estimated by a microassay which involves extraction of nuclear pellets with a heparin-containing buffer, exchange labeling of… CONTINUE READING