Prediction of the precipitation profiles of weak base drugs in the small intestine using a simplified transfer ("dumping") model coupled with in silico modeling and simulation approach.

@article{Kambayashi2016PredictionOT,
  title={Prediction of the precipitation profiles of weak base drugs in the small intestine using a simplified transfer ("dumping") model coupled with in silico modeling and simulation approach.},
  author={Atsushi Kambayashi and Takehiko Yasuji and Jennifer Boehm Dressman},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2016},
  volume={103},
  pages={
          95-103
        }
}
BACKGROUND Precipitation of poorly soluble, weakly basic drugs upon entering the small intestine may lead to poor bioavailability. It would be useful to be able to predict the extent of in vivo precipitation so that formulation measures to counteract this problem can be taken. AIM The aim of this research was to characterize the precipitation kinetics of two representative weak base drugs, dipyridamole and ketoconazole in vitro using a simplified transfer model approach, and to establish a… CONTINUE READING

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