Prediction of the likelihood of drug interactions with kinase inhibitors based on in vitro and computational studies.

Abstract

Kinase inhibitors (KIs) represent an important group of anticancer drugs, and many of them are substrates and inhibitors of human cytochrome P450s (CYPs), raising the potential of harmful drug interactions. This study investigated the effect of a library of KIs (n = 91) including 11 FDA-approved KIs on human CYP1A2, 2D6, 2C9, and 3A4 using high-throughput… (More)
DOI: 10.1111/fcp.12069

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