Prediction of the affinity of the TATA-binding protein to TATA boxes with single nucleotide polymorphisms

@article{Ponomarenko2009PredictionOT,
  title={Prediction of the affinity of the TATA-binding protein to TATA boxes with single nucleotide polymorphisms},
  author={Petr M. Ponomarenko and Mikhail P. Ponomarenko and Irina A. Drachkova and Marina V Lysova and Tatjana V. Arshinova and Ludmila K. Savinkova and Nikolay A. Kolchanov},
  journal={Molecular Biology},
  year={2009},
  volume={43},
  pages={472-479}
}
The TATA-binding protein (TBP) is the subunit of basal transcription factor TFIID that recognizes the TATA boxes of TATA-containing promoters in class II genes, binds to them, and starts the assemblage of the RNA polymerase II basal transcription complex. The sequence of the TATA box with its flanking regions affects the levels of basal and activated transcription. The association of polymorphic TATA boxes with human hereditary diseases supports the hypothesis that TBP-TATA interaction… CONTINUE READING

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