Prediction of the Intestinal Absorption of Endothelin Receptor Antagonists Using Three Theoretical Methods of Increasing Complexity

@article{Stenberg1999PredictionOT,
  title={Prediction of the Intestinal Absorption of Endothelin Receptor Antagonists Using Three Theoretical Methods of Increasing Complexity},
  author={Patric Stenberg and Kristina Luthman and Harma M Ellens and Chao Pin Lee and Philip L. Smith and Amparo M Lago and John D. Elliott and Per Artursson},
  journal={Pharmaceutical Research},
  year={1999},
  volume={16},
  pages={1520-1526}
}
Purpose. Three new computational strategies have been evaluated for their ability to predict intestinal membrane permeability to a series of endothelin receptor antagonists. Methods. The three methods were evaluated using a set of ten non-peptide endothelin receptor antagonists. The simplest method, 'the rule of five', is based on 2D parameters such as the number of potential hydrogen bonds, molecular weight and calculated lipophilicity. A method based on molecular mechanics calculations is… CONTINUE READING

From This Paper

Topics from this paper.
7 Citations
0 References
Similar Papers

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…