Prediction of tacrolimus metabolism and dosage requirements based on CYP3A4 phenotype and CYP3A5*3 genotype in Chinese renal transplant recipients

@article{Luo2016PredictionOT,
  title={Prediction of tacrolimus metabolism and dosage requirements based on CYP3A4 phenotype and CYP3A5*3 genotype in Chinese renal transplant recipients},
  author={Xi Luo and Li-jun Zhu and Ning-fang Cai and Li-yun Zheng and Ze-neng Cheng},
  journal={Acta Pharmacologica Sinica},
  year={2016},
  volume={37},
  pages={555-560}
}
Aim:To examine how the endogenous CYP3A4 phenotype and CYP3A5*3 genotype of Chinese renal transplant recipients influenced the dose-corrected trough concentration (C0/D) and weight-corrected daily dose (D/W) of tacrolimus.Methods:A total of 101 medically stable kidney transplant recipients were enrolled, and their blood and urine samples were gathered. The endogenous CYP3A4 phenotype was assessed by the ratio of 6β-hydroxycortisol and 6β-hydroxycortisone to cortisol and cortisone in urine… CONTINUE READING
4 Citations
14 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 14 references

Similar Papers

Loading similar papers…