Prediction of structures of multidomain proteins from structures of the individual domains.

@article{Wollacott2006PredictionOS,
  title={Prediction of structures of multidomain proteins from structures of the individual domains.},
  author={Andrew M Wollacott and Alexandre Zanghellini and Paul L. Murphy and David Baker},
  journal={Protein science : a publication of the Protein Society},
  year={2006},
  volume={16 2},
  pages={
          165-75
        }
}
We describe the development of a method for assembling structures of multidomain proteins from structures of isolated domains. The method consists of an initial low-resolution search in which the conformational space of the domain linker is explored using the Rosetta de novo structure prediction method, followed by a high-resolution search in which all atoms are treated explicitly and backbone and side chain degrees of freedom are simultaneously optimized. The method recapitulates, often with… CONTINUE READING

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