Prediction of stability in pharmaceutical preparations. VI. Stability, products, and mechanism in the pyrolytic degradation of aspirin anhydride.

@article{Garrett1959PredictionOS,
  title={Prediction of stability in pharmaceutical preparations. VI. Stability, products, and mechanism in the pyrolytic degradation of aspirin anhydride.},
  author={Edward R. Garrett and Edward L Schumann and Marvin F. Grostic},
  journal={Journal of the American Pharmaceutical Association. American Pharmaceutical Association},
  year={1959},
  volume={48},
  pages={
          684-91
        }
}
The effects of crystallizing solvent and moisture on the pyrolytic degradation of aspirin anhydride were studied by infrared spectroscopy. The unexpected effects of “soft glass”-catalyzed surface decomposition were observed. Micronization, drying, and avoidance of contact with alkali increased the thermal stability. A mechanism of acyl transfer in the formed melt adequately exlains the products identified by isolation and infrared studies. 

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