Prediction of skin permeability of drugs. I. Comparison with artificial membrane.

@article{Hatanaka1990PredictionOS,
  title={Prediction of skin permeability of drugs. I. Comparison with artificial membrane.},
  author={Tomomi Hatanaka and M Inuma and Kenji Sugibayashi and Yasunori Morimoto},
  journal={Chemical & pharmaceutical bulletin},
  year={1990},
  volume={38 12},
  pages={3452-9}
}
In order to measure the contribution of lipid and pore (aqueous) pathways to the total skin permeation of drugs, and to establish a predictive method for the steady state permeation rate of drugs, the relationship between permeability through excised hairless rat skin and some physicochemical properties of several drugs were compared with those through polydimethylsiloxane (silicone) and poly(2-hydroxyethyl methacrylate) (pHEMA) membranes, as typical solution-diffusion and porous membranes… CONTINUE READING
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