Prediction of residues in discontinuous B-cell epitopes using protein 3D structures.

  title={Prediction of residues in discontinuous B-cell epitopes using protein 3D structures.},
  author={Pernille Haste Andersen and Morten Nielsen and Ole Lund},
  journal={Protein science : a publication of the Protein Society},
  volume={15 11},
Discovery of discontinuous B-cell epitopes is a major challenge in vaccine design. Previous epitope prediction methods have mostly been based on protein sequences and are not very effective. Here, we present DiscoTope, a novel method for discontinuous epitope prediction that uses protein three-dimensional structural data. The method is based on amino acid statistics, spatial information, and surface accessibility in a compiled data set of discontinuous epitopes determined by X-ray… CONTINUE READING

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