Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy.

@article{Abanades2011PredictionOR,
  title={Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy.},
  author={Sergio Abanades and Jasper van der Aart and Julien A R Barletta and Carmine Marzano and Graham E. Searle and Cristian A. Salinas and Javaad J Ahmad and Richard R Reiley and Sabina Pampols-Maso and Stefano Zamuner and Vincent J. Cunningham and Eugenii A. Rabiner and Marc Laruelle and Roger N. Gunn},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2011},
  volume={31 3},
  pages={944-52}
}
Positron emission tomography (PET) is used in drug development to assist dose selection and to establish the relationship between blood and tissue pharmacokinetics (PKs). We present a new biomathematical approach that allows prediction of repeat-dose (RD) brain target occupancy (TO) using occupancy data obtained after administration of a single dose (SD). A PET study incorporating a sequential adaptive design was conducted in 10 healthy male adults who underwent 4 PET scans with [(11)C]DASB… CONTINUE READING
25 Citations
27 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 27 references

A dose-finding study

  • S Tanada, T Suhara
  • 2006

Similar Papers

Loading similar papers…