Prediction of protein-protein interaction sites using electrostatic desolvation profiles.

@article{Fiorucci2010PredictionOP,
  title={Prediction of protein-protein interaction sites using electrostatic desolvation profiles.},
  author={S{\'e}bastien Fiorucci and Martin Zacharias},
  journal={Biophysical journal},
  year={2010},
  volume={98 9},
  pages={1921-30}
}
Protein-protein complex formation involves removal of water from the interface region. Surface regions with a small free energy penalty for water removal or desolvation may correspond to preferred interaction sites. A method to calculate the electrostatic free energy of placing a neutral low-dielectric probe at various protein surface positions has been designed and applied to characterize putative interaction sites. Based on solutions of the finite-difference Poisson equation, this method also… CONTINUE READING