Prediction of protein functions based on function-function correlation relations

  title={Prediction of protein functions based on function-function correlation relations},
  author={Ka-Lok Ng and Jin-Shuei Ciou and Chien-Hung Huang},
  journal={Computers in biology and medicine},
  volume={40 3},
A protein function pair approach, based on protein-protein interaction (PPI) data, is proposed to predict protein functions. Randomization tests are performed on the PPI dataset, which resulted in a protein function correlation scoring value which is used to rank the relative importance of a function pair. It has been found that certain classes of protein functions tend to be correlated together. Scoring values of these correlation pairs allow us to predict the functionality of a protein given… CONTINUE READING
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