Prediction of protein domain boundaries from sequence alone.

@article{Galzitskaya2003PredictionOP,
  title={Prediction of protein domain boundaries from sequence alone.},
  author={Oxana V. Galzitskaya and Bogdan S Melnik},
  journal={Protein science : a publication of the Protein Society},
  year={2003},
  volume={12 4},
  pages={
          696-701
        }
}
We present here a simple approach to identify domain boundaries in proteins of an unknown three-dimensional structure. Our method is based on the hypothesis that a high-side chain entropy of a region in a protein chain must be compensated by a high-residue interaction energy within the region, which could correlate with a well-structured part of the globule, that is, with a domain unit. For protein domains, this means that the domain boundary is conditioned by amino acid residues with a small… CONTINUE READING
Highly Cited
This paper has 53 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS, ESTIMATED 51% COVERAGE

53 Citations

05'06'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 53 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 20 REFERENCES

Similar Papers

Loading similar papers…