Prediction of potential for organ donation after cardiac death in patients in neurocritical state: a prospective observational study

@article{Rabinstein2012PredictionOP,
  title={Prediction of potential for organ donation after cardiac death in patients in neurocritical state: a prospective observational study},
  author={A. Rabinstein and A. Yee and J. Mandrekar and J. Fugate and Y. D. Groot and E. Kompanje and L. Shutter and W. Freeman and Michael A. Rubin and E. Wijdicks},
  journal={The Lancet Neurology},
  year={2012},
  volume={11},
  pages={414-419}
}
BACKGROUND Successful donation of organs after cardiac death (DCD) requires identification of patients who will die within 60 min of withdrawal of life-sustaining treatment (WLST). We aimed to validate a straightforward model to predict the likelihood of death within 60 min of WLST in patients with irreversible brain injury. METHODS In this multicentre, observational study, we prospectively enrolled consecutive comatose patients with irreversible brain injury undergoing WLST at six medical… Expand
Prediction of potential for organ donation after circulatory death in neurocritical patients.
  • Guixing Xu, Zhiyong Guo, +8 authors Xiao-shun He
  • Medicine
  • The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
  • 2018
TLDR
The C-DCD-Nomogram is superior to the other 3 tools for predicting death within a limited duration after withdrawal of life-sustaining treatment in Chinese neurocritical patients and appears to be a reliable tool identifying potential donors after circulatory death. Expand
Predict cardiac death after withdrawal of life-supporting treatment in the neurocritical patients: a neurological score
With mortality rates ranging from 30% to 45%, severe traumatic brain injury (Glasgow coma scale≤5) is a leading cause of death. 2 The ability to predict outcome accurately is important for earlyExpand
Prediction Model for Timing of Death in Potential Donors After Circulatory Death (DCD III): Protocol for a Multicenter Prospective Observational Cohort Study
TLDR
This study will provide a robust multimodal prediction model, based on clinical and physiological parameters, that can predict time to circulatory arrest in cDCD donors and will fill an important knowledge gap in this essential field of health care. Expand
Nomogram for Predicting Time to Death After Withdrawal of Life‐Sustaining Treatment in Patients With Devastating Neurological Injury
  • X. He, G. Xu, +8 authors Z. Guo
  • Medicine
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2015
TLDR
A nomogram is developed and validated to accurately identify potential cardiac death donors in neurocritical patients in a Chinese population and indicated distinct prognoses between patients in the different risk groups. Expand
External Validation of the DCD-N Score and a Linear Prediction Model to Identify Potential Candidates for Organ Donation After Circulatory Death: A Nationwide Multicenter Cohort Study
TLDR
An external validation of 2 existing prediction models to identify potentially DCD candidates, using one of the largest cohorts, showed good discrimination but poor calibration for predicting the probability of death within 60 min. Expand
External validation of prediction models for time to death in potential donors after circulatory death
TLDR
Multivariable regression analysis demonstrated that absent cough‐, corneal reflex, lower morphine dosage, and midazolam use were significantly associated with death within 60 minutes after WSLT and previously developed prediction models were validated. Expand
Donation after circulatory determination of death in western Canada: a multicentre study of donor characteristics and critical care practices
TLDR
There is significant variability in critical care DCD practices in western Canada, but this has not resulted in significant differences in recipient or graft survival. Expand
Predicting time to death after withdrawal of life-sustaining therapy
TLDR
While the risk factors controlled ventilation, oxygenation, vasopressors, level of consciousness, and brainstem reflexes have been most consistently found to be associated with time to death, the addition of novel predictors, such as physician opinion and simultaneous withdrawal of all support, warrant further investigation. Expand
Eligibility of patients withheld or withdrawn from life-sustaining treatment to organ donation after circulatory arrest death: epidemiological feasibility study in a French Intensive Care Unit
TLDR
A French multicenter survey of end-of-life practices in ICU may help to identify potential appropriate organ donors and to interpret nation-specific considerations of the related professional, legal, and ethical frameworks. Expand
Donation after cardiac death: enter the neurologist
TLDR
In a study reported in this issue of The Lancet Neurology, Rabinstein and colleagues have tested a neurologicallybased scoring system that should increase the accuracy of donor selection and report a prospective observational study that aimed to validate the use of a neurological scoring system to assess likelihood of death within 60 min after WLST. Expand
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