Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data.

@article{Christensen2006PredictionOP,
  title={Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data.},
  author={Hege Christensen and Molly Baker and Geoffrey T. Tucker and Amin Rostami-Hodjegan},
  journal={Journal of pharmaceutical sciences},
  year={2006},
  volume={95 12},
  pages={2778-87}
}
Although displacement from plasma protein binding (dPB) is usually of little clinical significance, it should be taken into account when interpreting changes in total plasma concentrations of drugs subject to metabolically based drug-drug interactions (mDDI). The aim of this study was to develop an approach to predict changes in the free fractions (fu) of pairs of drugs that compete for plasma binding, knowing their binding affinity constants, and to consider the implications of associated… CONTINUE READING