Prediction of phenotype for acetylation and for debrisoquine hydroxylation by DNA-tests in healthy human volunteers

@article{Graf1992PredictionOP,
  title={Prediction of phenotype for acetylation and for debrisoquine hydroxylation by DNA-tests in healthy human volunteers},
  author={Thomas Graf and Franck Broly and Frank Hoffmann and Mario C O Probst and Urs A. Meyer and PD Dr. H. Howald},
  journal={European Journal of Clinical Pharmacology},
  year={1992},
  volume={43},
  pages={399-403}
}
The debrisoquine/sparteine-type polymorphism of drug oxidation and the polymorphism for acetylation are two common inherited variations in human drug metabolism. The phenotypes for hydroxylation and acetylation can be predicted be newly developed methods based on mutation-specific amplification of DNA by the polymerase chain reaction (PCR), which also allow for identification of heterozygous carriers of one mutant allele. In the present study, the results of genotyping of 81 healthy European… CONTINUE READING
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