Prediction of phenotype and gene expression for combinations of mutations

  title={Prediction of phenotype and gene expression for combinations of mutations},
  author={Gregory W. Carter and S. Prinz and Christine Neou and Johanna Shelby and Bruz Marzolf and Vesteinn Thorsson and Timothy Galitski},
  journal={Molecular Systems Biology},
  pages={96 - 96}
Molecular interactions provide paths for information flows. Genetic interactions reveal active information flows and reflect their functional consequences. We integrated these complementary data types to model the transcription network controlling cell differentiation in yeast. Genetic interactions were inferred from linear decomposition of gene expression data and were used to direct the construction of a molecular interaction network mediating these genetic effects. This network included both… CONTINUE READING