Prediction of overall survival through circadian rest-activity monitoring during chemotherapy for metastatic colorectal cancer.

@article{Innominato2012PredictionOO,
  title={Prediction of overall survival through circadian rest-activity monitoring during chemotherapy for metastatic colorectal cancer.},
  author={Pasquale F Innominato and Sylvie Giacchetti and G A Georg Bjarnason and Christian Focan and Carlo Garufi and Bruno Coudert and Stefano Iacobelli and Marco Tampellini and Xavier Durando and M Christine Mormont and J. B. Waterhouse and Francis A L{\'e}vi},
  journal={International journal of cancer},
  year={2012},
  volume={131 11},
  pages={2684-92}
}
The clinical relevance of circadian rhythm modifications in patients on chemotherapy is unknown. Even so, circadian parameter I<O before chemotherapy independently predicted overall survival. This study investigates the relevance of I<O measured during chemotherapy for survival and symptoms. The circadian rest-activity pattern was monitored for 3 days using a wristwatch actigraph while 77 patients were receiving a chemotherapy course within an international randomized Phase III trial. Treatment… CONTINUE READING
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