Prediction of oral drug absorption in humans by theoretical passive absorption model.

@article{Obata2005PredictionOO,
  title={Prediction of oral drug absorption in humans by theoretical passive absorption model.},
  author={Kouki Obata and Kiyohiko Sugano and Ryoichi Saitoh and Atsuko Higashida and Yoshiaki Nabuchi and Minoru Machida and Yosinori Aso},
  journal={International journal of pharmaceutics},
  year={2005},
  volume={293 1-2},
  pages={183-92}
}
The purpose of the present study was to examine the oral drug absorption predictability of the theoretical passive absorption model (TPAM). As chemical descriptors of drugs, the octanol/buffer distribution coefficient at pH 6.0 (D(ow)), intrinsic octanol-water partition coefficient (P(ow)), pK(a), and molecular weight (MW) were calculated from the chemical structure. Total passive intestinal membrane permeation consists of transcellular, paracellular and unstirred water layer (UWL) permeation… CONTINUE READING

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