Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring.

@article{Gutirrez2005PredictionON,
  title={Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring.},
  author={F{\'e}lix Guti{\'e}rrez and Andr{\'e}s Navarro and Sergio Padilla and Rosa Ant{\'o}n and Mar Masi{\'a} and J. Fern{\'a}ndez- Borr{\'a}s and Alberto Mart{\'i}n-Hidalgo},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2005},
  volume={41 11},
  pages={1648-53}
}
BACKGROUND Data on long-term central nervous system (CNS) toxicity associated with efavirenz therapy are scarce, and risk factors remain largely unknown. We aimed to determine whether monitoring the plasma concentration of efavirenz could predict neuropsychiatric adverse events associated with long-term therapy with efavirenz. METHODS We performed a longitudinal study involving 17 consecutive human immunodeficiency virus (HIV)-infected subjects with virological suppression after at least 6… CONTINUE READING
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