Prediction of morphine dose in humans.

  title={Prediction of morphine dose in humans.},
  author={Nick H G Holford and Shu Chin Ma and Brian J Anderson},
  journal={Paediatric anaesthesia},
  volume={22 3},
BACKGROUND Morphine is widely used throughout the human life span. Several pharmacokinetic models have been proposed to predict how morphine clearance changes with weight and age. This study uses a large external data set to evaluate the ability of pharmacokinetic models to predict morphine doses. METHODS A data set of morphine clearance estimates was created from published reports in premature neonates, full-term neonates, infants, children, and adults. This external data set was used to… CONTINUE READING
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