Prediction of miRNA-mRNA associations in Alzheimer’s disease mice using network topology

Abstract

Little is known about the relationship between miRNA and mRNA expression in Alzheimer’s disease (AD) at early- or late-symptomatic stages. Sequence-based target prediction algorithms and anti-correlation profiles have been applied to predict miRNA targets using omics data, but this approach often leads to false positive predictions. Here, we applied the… (More)
DOI: 10.1186/1471-2164-15-644

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