Prediction of metabolic clearance using cryopreserved human hepatocytes: kinetic characteristics for five benzodiazepines.

@article{Hallifax2005PredictionOM,
  title={Prediction of metabolic clearance using cryopreserved human hepatocytes: kinetic characteristics for five benzodiazepines.},
  author={David Hallifax and Helen C Rawden and Nancy Hakooz and J. Brian Houston},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2005},
  volume={33 12},
  pages={1852-8}
}
Predictions of intrinsic clearance (CL(int)) from human liver microsomes often underestimate in vivo observations. In this study, a series of five benzodiazepines was used as prototypic CYP3A4 substrates to investigate the prediction of clearance from the less studied alternative in vitro system, cryopreserved human hepatocytes. Formation of the two major metabolites from midazolam, triazolam, diazepam, flunitrazepam, and alprazolam was measured in cryopreserved human hepatocytes from five… CONTINUE READING
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