Prediction of intestinal first-pass drug metabolism.

@article{Yang2007PredictionOI,
  title={Prediction of intestinal first-pass drug metabolism.},
  author={Jiansong Yang and Masoud Jamei and Karen Rowland Yeo and Geoffrey T. Tucker and Amin Rostami-Hodjegan},
  journal={Current drug metabolism},
  year={2007},
  volume={8 7},
  pages={
          676-84
        }
}
Despite a lower content of many drug metabolising enzymes in the intestinal epithelium compared to the liver (e.g. intestinal CYP3A abundance in the intestine is 1% that of the liver), intestinal metabolic extraction may be similar to or exceed hepatic extraction. Modelling of events on first-pass through the intestine requires attention to the complex interplay between passive permeability, active transport, binding, relevant blood flows and the intrinsic activity and capacity of enzyme… CONTINUE READING
BETA

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 112 CITATIONS

Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data.

  • Drug metabolism and disposition: the biological fate of chemicals
  • 2010
VIEW 6 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Disparity in intestine disposition between formed and preformed metabolites and implications: a theoretical study.

  • Drug metabolism and disposition: the biological fate of chemicals
  • 2009
VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2008
2018

CITATION STATISTICS

  • 22 Highly Influenced Citations

  • Averaged 12 Citations per year over the last 3 years

  • 16% Increase in citations per year in 2018 over 2017

Similar Papers

Loading similar papers…