Prediction of in vivo tumor response to chemotherapeutic agents by the in vitro sister chromatid exchange assay.

  title={Prediction of in vivo tumor response to chemotherapeutic agents by the in vitro sister chromatid exchange assay.},
  author={Philip J. Tofilon and Ivan Basic and Luka Milas},
  journal={Cancer research},
  volume={45 5},
The ability of the in vitro sister chromatid exchange (SCE) assay to predict in vivo tumor drug sensitivity was investigated using a spontaneous hepatocarcinoma in C3Hf/Kam mice and 3 chemotherapeutic agents: melphalan; cis-platinum; and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). For hepatocarcinoma cells grown in monolayer culture, melphalan was the most efficient at inducing SCEs, and BCNU, the least. cis-Platinum induced a range in SCEs that overlapped those of BCNU and melphalan… CONTINUE READING


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