Prediction of in vivo hepatic clearance from in vitro data using cryopreserved human hepatocytes.

@article{Bachmann2003PredictionOI,
  title={Prediction of in vivo hepatic clearance from in vitro data using cryopreserved human hepatocytes.},
  author={Kenneth A. Bachmann and James Byers and Rumi Ghosh},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2003},
  volume={33 5},
  pages={475-83}
}
1. Cryopreserved human hepatocytes were used to predict in vivo hepatic clearance (CL(hepatic)) from estimates of in vitro intrinsic clearance (CL' int). 2. (CL' int) was estimated for phenytoin, valproic acid, carbamazepine, theophylline, quinidine and procainamide after their addition to hepatocytes suspended either in human serum or in serum-free media. (CL' int)was estimated from in vitro concentration versus time data fitted to a monoexponential decay model. (CL' int) was estimated from… CONTINUE READING

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