Prediction of in Vitro Hepatic Biliary Excretion using Stochastic Agent-Based Modeling and Fuzzy Clustering

@article{SheikhBahaei2006PredictionOI,
  title={Prediction of in Vitro Hepatic Biliary Excretion using Stochastic Agent-Based Modeling and Fuzzy Clustering},
  author={Shahab Sheikh-Bahaei and C. Anthony Hunt},
  journal={Proceedings of the 2006 Winter Simulation Conference},
  year={2006},
  pages={1617-1624}
}
We present a method for estimating (predicting) parameter values for an agent-based model of in silico hepatocytes (ISH). The method enables the ISH to interact with simulated drugs to reasonably match results from in vitro hepatocyte excretion studies. Further, we make the estimation method available to the model, itself, to enable it to reasonably anticipate (predict) the biliary transport and excretion properties of a new compound based on the acceptable parameter values for previously… CONTINUE READING

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In silico hepatocyte: agent-based modeling of the biliary excretion of drugs in vitro

  • S. Sheikh-Bahaei, G.E.P. Ropella, C. A. Hunt.
  • Proceedings of the 1624
  • 2006
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