Prediction of human clearance based on animal data and molecular properties.

@article{Huang2015PredictionOH,
  title={Prediction of human clearance based on animal data and molecular properties.},
  author={Wenkang Huang and Lv Geng and R. Q. Deng and Shaoyong Lu and Guangli Ma and Jianxiu Yu and Jian Zhang and Wei Liu and Tingjun Hou and Xuefeng Lu},
  journal={Chemical biology & drug design},
  year={2015},
  volume={86 5},
  pages={990-7}
}
Human clearance is often predicted prior to clinical study from in vivo preclinical data by virtue of interspecies allometric scaling methods. The aims of this study were to determine the important molecular descriptors for the extrapolation of animal data to human clearance and further to build a model to predict human clearance by combination of animal… CONTINUE READING