Prediction of human pharmacokinetics--gastrointestinal absorption.

  title={Prediction of human pharmacokinetics--gastrointestinal absorption.},
  author={Urban Fagerholm},
  journal={The Journal of pharmacy and pharmacology},
  volume={59 7},
Permeability (P(e)) and solubility/dissolution are two major determinants of gastrointestinal (GI) drug absorption. Good prediction of these is crucial for predicting doses, exposures and potential interactions, and for selecting appropriate candidate drugs. The main objective was to evaluate screening methods for prediction of GI P(e), solubility/dissolution and fraction absorbed (f(a)) in humans. The most accurate P(e) models for prediction of f(a) of passively transported and highly soluble… CONTINUE READING