Prediction of hepatic microsomal intrinsic clearance and human clearance values for drugs.

@article{Nikolic2009PredictionOH,
  title={Prediction of hepatic microsomal intrinsic clearance and human clearance values for drugs.},
  author={Katarina Nikolic and Danica Agababa},
  journal={Journal of molecular graphics & modelling},
  year={2009},
  volume={28 3},
  pages={245-52}
}
Twenty-nine drugs of different structures were used in theoretical QSAR analysis of human hepatic microsomal intrinsic clearance (in vitro T(1/2) and in vitro CL'(int)) and whole body clearance (CL(blood)). The examined compounds demonstrated a wide range of scaled intrinsic clearance values. Constitutional, geometrical, physico-chemical and electronic descriptors were computed for the examined structures by use of the Marvin Sketch 5.1.3_2, the Chem3D Ultra 7.0.0 and the Dragon 5.4 program… CONTINUE READING

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