Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method.

@article{Shibata2002PredictionOH,
  title={Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method.},
  author={Yoshihiro Shibata and Hiroyuki Takahashi and Masato Chiba and Yasuyuki Ishii},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 8},
  pages={892-6}
}
A novel and convenient method was established for the prediction of in vivo metabolic clearance in human liver. The present method applied the in vitro-in vivo extrapolation paradigm previously established in rats to the in vitro data obtained from cryopreserved human hepatocytes. Predicted hepatic availability and clearance were compared with the reported oral bioavailability and plasma clearance in humans for 14 clinically used drugs (naloxone, buspirone, verapamil, lidocaine, imipramine… CONTINUE READING

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