Prediction of functionally important residues based solely on the computed energetics of protein structure.

@article{Elcock2001PredictionOF,
  title={Prediction of functionally important residues based solely on the computed energetics of protein structure.},
  author={Adrian H. Elcock},
  journal={Journal of molecular biology},
  year={2001},
  volume={312 4},
  pages={885-96}
}
Catalytic and other functionally important residues in proteins can often be mutated to yield more stable proteins. Many of these residues are charged residues that are located in electrostatically unfavorable environments. Here it is demonstrated that because continuum electrostatics methods can identify these destabilizing residues, the same methods can also be used to identify functionally important residues in otherwise uncharacterized proteins. To establish this point, detailed… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 89 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Structural proteomics of an archaeon

  • D. Christendat, A. Yee, +4 authors R J.
  • Nature Struct. Biol
  • 2000
Highly Influential
3 Excerpts

Computer simulation of protein-protein interactions

  • A. H. Elcock, D. Sept, J. A. McCammon
  • J. Phys. Chem. ser. B,
  • 2001
2 Excerpts

reading evolutionary signals about stability, folding kinetics and function

  • L. Mirny, Shakhnovich, E. I. . Universally conserved positions in protein folds
  • J. Mol. Biol. 291, 177-196. Edited by B. Honig
  • 2001
2 Excerpts

Similar Papers

Loading similar papers…