Prediction of functional modules based on comparative genome analysis and Gene Ontology application

@article{Wu2005PredictionOF,
  title={Prediction of functional modules based on comparative genome analysis and Gene Ontology application},
  author={Hongwei Wu and Zhengchang Su and Fenglou Mao and Victor Olman and Ying Xu},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={2822 - 2837}
}
We present a computational method for the prediction of functional modules encoded in microbial genomes. In this work, we have also developed a formal measure to quantify the degree of consistency between the predicted and the known modules, and have carried out statistical significance analysis of consistency measures. We first evaluate the functional relationship between two genes from three different perspectives--phylogenetic profile analysis, gene neighborhood analysis and Gene Ontology… CONTINUE READING
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Statistical Inference, 2nd edn

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