Prediction of drug-related morphological changes of the T wave

  title={Prediction of drug-related morphological changes of the T wave},
  author={M Tj{\"a}derborn and Maria Aunes-Jansson and Emma Samuelsson and Lars Frison and Susanne Johansson and Anders R Berggren and Nils G Edvardsson},
  journal={Scandinavian Cardiovascular Journal},
  pages={215 - 222}
Abstract Objectives. To describe the characteristics of patients presenting with morphological T wave changes that lead to measurement difficulties, and to identify possible predictors of such changes at baseline and early after start of treatment. Design. ECGs from 145 patients receiving a combined potassium and sodium channel blocking agent for conversion of atrial fibrillation (AF), underwent semiautomatic analysis in a digitalized high-precision analysis program. In 15 patients, one or more… 



QT Interval: How to Measure It and What Is “Normal”

Methods for clinically relevant visual and manual assessment of QT-interval duration from a 12-lead ECG, which can be utilized in day-today practice for the diagnosis of long QT syndrome (LQTS) and other repolarization disorders are focused on.

Quantitative Analysis of T‐wave Morphology Increases Confidence in Drug‐Induced Cardiac Repolarization Abnormalities: Evidence From the Investigational IKr Inhibitor Lu 35–138

As a covariate to the assessment of QT interval liability, MCS offered important additive information to the effect of Lu 35–138 on cardiac repolarization.

Drug induced QT prolongation.

  • W. Zareba
  • Medicine, Biology
    Cardiology journal
  • 2007
Since drugs affecting repolarization not only prolong QT but also they alter T wave morphology, novel computerized methods quantifying these changes are being developed to assist physicians and drug manufacturers in monitoring safety of the drugs.

Risk factors for prolonged QTc among US adults: Third National Health and Nutrition Examination Survey

  • S. BenoitA. MendelsohnP. NourjahJ. StaffaD. Graham
  • Medicine
    European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
  • 2005
Healthcare practitioners should be aware that a prolonged QTc interval is a potential indicator of cardiovascular risk, and should exercise caution in prescribing potentially QT-prolonging medications to certain patients.

Drug-induced QT prolongation and proarrhythmia: an inevitable link?

  • K. AhmadP. Dorian
  • Medicine
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
  • 2007
The presumed relationship between the QT interval and myocardial repolarization will be deconstructed, demonstrating that most of the important aspects ofRepolarization, and subsequent arrhythmogenesis, cannot be understood only through the simple numerical measurement of theQT interval.

Drug-induced QT-interval prolongation and proarrhythmic risk in the treatment of atrial arrhythmias.

  • E. ShantsilaT. WatsonG. Lip
  • Biology, Medicine
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
  • 2007
Electrophysiological drug effects found to be important in the etiology of proarrhythmia include QT-interval prolongation through selective blockade of the delayed rectifying potassium current (I(Kr), early afterdepolarizations, transmural dispersion of repolarization, and a reverse rate dependence.

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

In hearts in which late INa is augmented to mimic congenital or acquired pathological conditions, amiodarone has a concentration-dependent biphasic effect to induce and then suppress arrhythmic activity, secondary to inhibition of HERG K+ and late Na+ currents.

Genotype-Phenotype Correlation in the Long-QT Syndrome: Gene-Specific Triggers for Life-Threatening Arrhythmias

Life-threatening arrhythmias in LQTS patients tend to occur under specific circumstances in a gene-specific manner, allowing new insights into the mechanisms that relate the electrophysiological consequences of mutations on specific genes to clinical manifestations and offer the possibility of complementing traditional therapy with gene- specific approaches.


Both electrical and mechanical records are useful in considering the relative duration of systole and diastole, and it will be seen that almost exactly similar figures are obtained by calculation from the formula systoles = K Vcycle.