Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data

@article{Nakasa1998PredictionOD,
  title={Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data},
  author={Hiromitsu Nakasa and H. Nakamura and S Ono and M Tsutsui and Masahiro Kiuchi and Shigeru Ohmori and Mitsukazu Kitada},
  journal={European Journal of Clinical Pharmacology},
  year={1998},
  volume={54},
  pages={177-183}
}
Objective: The purposes of this study were to identify the P450 enzyme (CYP) responsible for zonisamide metabolism in humans by using expressed human CYPs and to predict drug interaction of zonisamide in vivo from in vitro data. Methods: Ten expressed human CYPs and human liver microsomes were used in the experiments for the identification of enzymes responsible for zonisamide metabolism and for the prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data… 
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46 Citations
Highly Influential Citations
2
Background Citations
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Methods Citations
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Results Citations
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46 Citations

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Update on the Genetic Polymorphisms of Drug-Metabolizing Enzymes in Antiepileptic Drug Therapy
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The state of research on the effects of mutations of drug-metabolizing enzymes on the pharmacokinetics and pharmacodynamics of AED therapies is summarized and future directions for the dose-adjustment of A ED are discussed.
Identification of cytochrome P-450 isoform(s) responsible for the metabolism of pimobendan in human liver microsomes.
TLDR
It is concluded that CYP1A2 is one of the major enzymes responsible for the O-demethylation of pimobendan and CYP3A may make a minor contribution at clinically relevant concentrations of the drug.
A Mechanistic Approach to Antiepileptic Drug Interactions
  • G. Anderson
  • Biology, Medicine
    The Annals of pharmacotherapy
  • 1998
TLDR
By understanding the mechanisms of drug interactions, the pharmacist can play a key role in patient care by anticipating and preventing AED drug interactions.
Effects of the Antifungal Agents on Oxidative Drug Metabolism
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The interactions of ketoconazole with cyclosporin and tacrolimus have been applied for therapeutic purposes to allow a lower dosage and cost of the immunosuppressant and a reduced risk of fungal infections.
Population Estimation Regarding the Effects of Cytochrome P450 2C19 and 3A5 Polymorphisms on Zonisamide Clearance
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It is demonstrated that the CYP2C19 genotype affects the ZNS metabolism in Japanese epileptic subjects and the clinical relevance of these changes remains to be explored in future studies.
Quantitative Drug Interactions Prediction System (Q-DIPS)
TLDR
A computerised application, the quantitative drug interactions prediction system (Q-DIPS), to make both qualitative deductions and quantitative predictions on the basis of a database containing updated information on CYP substrates, inhibitors and inducers, as well as pharmacokinetic parameters is developed.
Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs
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It is suggested that micafungin and amphotericin B would be unlikely to cause drug‐drug interactions by inhibition of CYP3A4 and MDR1 and the physicochemical mechanisms involved and impact on clinical treatment should be studied further.
Effects of CYP2C19 and P450 Oxidoreductase Polymorphisms on the Population Pharmacokinetics of Clobazam and N-Desmethylclobazam in Japanese Patients With Epilepsy
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The results suggest that determining the CYP2C19 and/or POR genotypes is helpful for obtaining appropriate serum CLB and N-CLB concentrations and preventing an overdose when starting CLB therapy.
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