Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data

@article{Nakasa1998PredictionOD,
  title={Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data},
  author={Hiromitsu Nakasa and H. Nakamura and S Ono and M Tsutsui and Masahiro Kiuchi and Shigeru Ohmori and Mitsukazu Kitada},
  journal={European Journal of Clinical Pharmacology},
  year={1998},
  volume={54},
  pages={177-183}
}
Objective: The purposes of this study were to identify the P450 enzyme (CYP) responsible for zonisamide metabolism in humans by using expressed human CYPs and to predict drug interaction of zonisamide in vivo from in vitro data. Methods: Ten expressed human CYPs and human liver microsomes were used in the experiments for the identification of enzymes responsible for zonisamide metabolism and for the prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data… Expand
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