Prediction of drug-ABC-transporter interaction--Recent advances and future challenges.

  title={Prediction of drug-ABC-transporter interaction--Recent advances and future challenges.},
  author={Floriane Montanari and Gerhard F. Ecker},
  journal={Advanced drug delivery reviews},
With the discovery of P-glycoprotein (P-gp), it became evident that ABC-transporters play a vital role in bioavailability and toxicity of drugs. They prevent intracellular accumulation of toxic compounds, which renders them a major defense mechanism against xenotoxic compounds. Their expression in cells of all major barriers (intestine, blood-brain barrier, blood-placenta barrier) as well as in metabolic organs (liver, kidney) also explains their influence on the ADMET properties of drugs and… CONTINUE READING
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