Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival

@article{Gyrffy2005PredictionOD,
  title={Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival},
  author={Balazs Gy{\"o}rffy and Violeta Serra and Karsten Juerchott and Rula Abdul-Ghani and Mitch Garber and Ulrike Stein and Iver Petersen and Hermann Lage and Manfred Dietel and Reinhold Sch{\"a}fer},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={7542-7551}
}
Up to date clinical tests for predicting cancer chemotherapy response are not available and individual markers have shown little predictive value. We hypothesized that gene expression patterns attributable to chemotherapy-resistant cells can predict response and cancer prognosis. We contrasted the expression profiles of 13 different human tumor cell lines of gastric (EPG85–257), pancreatic (EPP85–181), colon (HT29) and breast (MCF7 and MDA-MB-231) origin and their counterparts resistant to the… CONTINUE READING
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