Prediction of copper transport protein 1 (CTR1) genotype on severe cisplatin induced toxicity in non-small cell lung cancer (NSCLC) patients.

@article{Xu2012PredictionOC,
  title={Prediction of copper transport protein 1 (CTR1) genotype on severe cisplatin induced toxicity in non-small cell lung cancer (NSCLC) patients.},
  author={Xiaojing Xu and Huayi Ren and Bo-ting Zhou and Yingchun Zhao and Ruixia Yuan and Rui Ma and Honghao Zhou and Zhaoqian Liu},
  journal={Lung cancer},
  year={2012},
  volume={77 2},
  pages={438-42}
}
BACKGROUND Cisplatin toxicity severely obstacles successful chemotherapy in lung cancer patients. Cisplatin uptake is considered as one of the major factors contributing to the side effects of cisplatin. Genetic variances of core genes also affect cisplatin toxicity. It has been identified that CTR1, copper transporter protein 1, plays an essential role in cisplatin uptake. The purpose of this study is to investigate whether CTR1 polymorphism is associated with platinum toxicity in non-small… CONTINUE READING
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