Prediction of complete gene structures in human genomic DNA.

@article{Burge1997PredictionOC,
  title={Prediction of complete gene structures in human genomic DNA.},
  author={Christopher B. Burge and Samuel Karlin},
  journal={Journal of molecular biology},
  year={1997},
  volume={268 1},
  pages={
          78-94
        }
}
We introduce a general probabilistic model of the gene structure of human genomic sequences which incorporates descriptions of the basic transcriptional, translational and splicing signals, as well as length distributions and compositional features of exons, introns and intergenic regions. Distinct sets of model parameters are derived to account for the many substantial differences in gene density and structure observed in distinct C + G compositional regions of the human genome. In addition… 

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