Prediction of common secondary structures of RNAs: a genetic algorithm approach.

@article{Chen2000PredictionOC,
  title={Prediction of common secondary structures of RNAs: a genetic algorithm approach.},
  author={J. H. K. Chen and S Y Le and Jacob V. Maizel},
  journal={Nucleic acids research},
  year={2000},
  volume={28 4},
  pages={991-9}
}
In this study we apply a genetic algorithm to a set of RNA sequences to find common RNA secondary structures. Our method is a three-step procedure. At the first stage of the procedure for each sequence, a genetic algorithm is used to optimize the structures in a population to a certain degree of stability. In this step, the free energy of a structure is the fitness criterion for the algorithm. Next, for each structure, we define a measure of structural conservation with respect to those in… CONTINUE READING