Prediction of cis/trans isomerization in proteins using PSI-BLAST profiles and secondary structure information

Abstract

The majority of peptide bonds in proteins are found to occur in the trans conformation. However, for proline residues, a considerable fraction of Prolyl peptide bonds adopt the cis form. Proline cis/trans isomerization is known to play a critical role in protein folding, splicing, cell signaling and transmembrane active transport. Accurate prediction of… (More)
DOI: 10.1186/1471-2105-7-124

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