Prediction of chemotherapy response in human leukemia using in vitro chemosensitivity test.

@article{Hwang1993PredictionOC,
  title={Prediction of chemotherapy response in human leukemia using in vitro chemosensitivity test.},
  author={Wayne S Hwang and Lee May Chen and Shao Hui Huang and Chih Chi Wang and Michael T. Tseng},
  journal={Leukemia research},
  year={1993},
  volume={17 8},
  pages={685-8}
}
We performed the dye exclusion assay (DEA) and the MTT dye reduction assay to determine the drug sensitivity of acute leukemia using short-term microplate cultures. The in vitro results were compared with the clinical response of 31 patients with acute leukemia treated by combination chemotherapy. The true-positive rates of the DEA and MTT assays were 86.7 and 91.3%, respectively; the true-negative rates were 33.3 and 77.8%, respectively; and the predictive accuracy was 62.5 and 87.5… CONTINUE READING

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