Prediction of chemotherapeutic response of colorectal liver metastases with dynamic gadolinium-DTPA-enhanced MRI and localized 19F MRS pharmacokinetic studies of 5-fluorouracil.

@article{Laarhoven2007PredictionOC,
  title={Prediction of chemotherapeutic response of colorectal liver metastases with dynamic gadolinium-DTPA-enhanced MRI and localized 19F MRS pharmacokinetic studies of 5-fluorouracil.},
  author={Hanneke W M van Laarhoven and Dennis W. J. Klomp and Mark Rijpkema and Yvonne L M Kamm and Dietrich Wagener and Jelle O. Barentsz and Cornelis J A Punt and Arend Heerschap},
  journal={NMR in biomedicine},
  year={2007},
  volume={20 2},
  pages={128-40}
}
Systemic chemotherapy is effective in only a subset of patients with metastasized colorectal cancer. Therefore, early selection of patients who are most likely to benefit from chemotherapy is desirable. Response to treatment may be determined by the delivery of the drug to the tumor, retention of the drug in the tumor and by the amount of intracellular uptake, metabolic activation and catabolism, as well as other factors. The first aim of this study was to investigate the predictive value of… CONTINUE READING

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