Prediction of breast tumor progression by integrity of free circulating DNA in serum.

  title={Prediction of breast tumor progression by integrity of free circulating DNA in serum.},
  author={Naoyuki Umetani and Armando E. Giuliano and Suzanne H Hiramatsu and Farin Amersi and Taku Nakagawa and Silvana Martino and Dave S. B. Hoon},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={24 26},
PURPOSE Cell-free DNA circulating in serum is a candidate molecular biomarker for malignant tumors. Unlike uniformly truncated DNA released from apoptotic cells, DNA released from dead cancer cells varies in size. Serum DNA integrity, the ratio of longer fragments to total DNA, may be clinically useful for detecting breast cancer progression. PATIENTS AND METHODS Serum samples from 51 healthy females and 83 females with primary breast cancers (eight American Joint Committee on Cancer stage 0… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 108 extracted citations

Prognostic Value of Free DNA Quantification in Serum and Cerebrospinal Fluid in Glioma Patients

Journal of Molecular Neuroscience • 2011
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…